Presentations
- Abnormal full blood count
- Bleeding
- Bruising
- Lethargy
- Recurrent infections
Conditions
- Acquired syndromes, such as:
- aplastic anaemia
- myelodysplastic syndrome (MDS)
- neutropenia:
- autoimmune
- chronic idiopathic
- thrombocytopenia (immune)
- Haemophagocytic lymphohistocytosis (HLH)
- Inherited syndromes, such as:
- neutropenia:
- thrombocytopenia
- Macrophage activation syndrome (MAS)
- Paroxysmal nocturnal haemoglobinuria (PNH)
- Primary myelofibrosis and secondary myelofibrosis
- Toxicity:
- drugs and viral pathogens such as
human parvovirus B19
For each presentation and condition, Advanced Trainees will know how to:
Synthesise
- recognise the clinical presentation
- identify relevant epidemiology, prevalence, pathophysiology, and clinical science
- take a comprehensive clinical history
- conduct an appropriate examination
- establish a differential diagnosis
- plan and arrange appropriate investigations
- consider the impact of illness and disease on patients and their quality of life when developing a management plan
Manage
- provide evidence-based management
- prescribe therapies tailored to patients’ needs and conditions
- recognise potential complications of disease and its management, and initiate preventative strategies
- involve multidisciplinary teams
Consider other factors
- identify individual and social factors and the impact of these on diagnosis and management
Conditions
- Disorders of histocytes and dendritic cells
- Inherited disorders of neutrophil function
- Inherited syndromes, such as:
- Diamond–Blackfan anaemia
- Fanconi anaemia
- Shwachman–Diamond syndrome
- telomeropathies
- Lysosomal storage disease
- Sideroblastic anaemias:
- acquired:
- drugs
- myelodysplastic syndrome (MDS)
- nutritional
- congenital
For each presentation and condition, Advanced Trainees will know how to:
Synthesise
- recognise the clinical presentation
- identify relevant epidemiology, prevalence, pathophysiology, and clinical science
- take a comprehensive clinical history
- conduct an appropriate examination
- establish a differential diagnosis
- plan and arrange appropriate investigations
- consider the impact of illness and disease on patients and their quality of life when developing a management plan
Manage
- provide evidence-based management
- prescribe therapies tailored to patients’ needs and conditions
- recognise potential complications of disease and its management, and initiate preventative strategies
- involve multidisciplinary teams
Consider other factors
- identify individual and social factors and the impact of these on diagnosis and management
- Clinical manifestations of bone marrow failure and pancytopenia
- Primary (idiopathic) and secondary causes of bone marrow aplasia,
such as:
- Treatment modalities of bone marrow aplasia
-
Bone marrow aplasia treatment, such as:
- antithymocyte globulin
- cessation of causative drugs
- cyclosporin
- other immune modulators
- stem cell transplantation
-
Bone marrow failure:
- bone marrow examination
- cytogenetic and molecular analyses
- full blood counts
- morphology
- viral serology
- Genetic analysis, including diagnostic and risk stratifying techniques
- Required monitoring and risk of transformation of the various congenital conditions
- Efficacy and toxicities evaluation of treatments
- Indications for transplant
